Jul 16, 2022
In Song Writing
The study found that people who had been vaccinated by a breakthrough infection with the early Omicron strain BA.1 produced antibodies that neutralized the BA.1 virus as well as the original COVID-19 virus, while subtypes that emerged later, including BA.2.12 .1, BA.4 and BA.5, all have mutations that escape these antibodies. These subtype variants were found to have greater escape ability to neutralizing antibodies in plasma from patients who received three doses of the vaccine and who were infected with Omicron BA.1 post-vaccination. Neutralizing antibodies inactivate the virus and help provide "broad-spectrum immune" protection. The team explained that the Omicron company banner design subtype variant can break through the humoral immunity (antibody immunity) protection triggered by the Omicron virus itself, and the memory immunity generated by this breakthrough infection is mainly directed against the original strain. Vaccines made with early Omicron variants have limited neutralization effects on emerging subtypes. In this regard, the Peking University research team believes that such vaccines may not be able to provide "broad-spectrum" immune protection against the new Omicron subtype variant. "Unlike when Omicron first appeared, the current Omicron subtype variants can target Omicron-induced humoral immunity (breakthrough infection), such as Omicron infection following vaccination," the study wrote. Omicron's breakthrough infection-induced memory immunity was primarily against the original COVID-19 strain, and "this in turn narrows the diversity of antibodies elicited and may further facilitate the emergence of future variants." unnamed Photo Credit: Getty Images / BBC News "Immunoprinting" The Imperial College London research team published a paper in the journal Science on June 14 , saying that Omicron infection does not necessarily enhance natural immunity to emerging virus variants and subtypes. The immune-enhancing effect of infection is more dependent on the individual's infection history.